Migraine is a chronic brain disorder, characterized by attacks of severe headache accompanied by nausea, vomiting and sensitivity to light, sound and smell. Attacks can be preceded by premonitory symptoms such as fatigue, muscular stiff ness or negative aff ect. It has been shown that cortical spreading depression, the trigeminovascular system and central sensitization play an important role in the pathophysiology of migraine. In addition, gene mutations appear to be responsible for lowering the threshold for stimuli in the hours before a migraine attack sets in. Therefore, genetic factors may induce susceptibility for migraine triggers such as stress, female hormones and skipping meals. Migraine is a common disorder aff ecting 12% of the general population in western societies (6% men, 17% women). The burden of migraine is high and patients’ well-being and ability to function are aff ected in several domains, such as work performance, mental health and social activities.

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Keywords behavioural treatment, lay trainers, migraine, patient empowerment, prevention, self-management
Promotor M.J. Sorbi (Marjolijn) , J. Passchier (Jan) , L.J.P. van Doomen
Publisher Erasmus MC: University Medical Center Rotterdam
Sponsor Nederlandse Hoofdpijn Vereniging, ZonMw, Merck Sharp & Dohme B.V., Erasmus University Medical Centre
ISBN 978-90-8559-461-1
Persistent URL hdl.handle.net/1765/20510
Mérelle, S.Y.M. (2008, December 3). Migraine Trainers as Models: the effectiveness of Lay trainerswith migraine for behavioural attack prevention. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/20510