Objective: Local anatomy and the patient's risk profile independently affect the expansion rate of an abdominal aortic aneurysm. We describe a hybrid method that combines finite element modelling and statistical methods to predict patient-specific aneurysm expansion. Methods: The 3-D geometry of the aneurysm was imaged with computed tomography. We used finite element methods to calculate wall stress and aneurysm expansion. Expansion rate was adjusted by risk factors obtained from a database of 80 patients. Aneurysm diameters predicted with and without the risk profiles were compared with diameters measured with ultrasound for 11 patients. Results: For this specific group of patients, local anatomy contributed 62% and the risk profile 38% to the aneurysmal expansion rate. Predictions with risk profiles resulted in smaller root mean square errors than predictions without risk profiles (2.9 vs. 4.0 mm, p < 0.01). Conclusions: This hybrid approach predicted aneurysmal expansion for a period of 30 months with high accuracy.

Additional Metadata
Keywords Abdominal aortic aneurysm, Mechanical stress, Risk factors, abdominal aorta aneurysm, aged, aorta rupture, aortography, article, biological model, computer assisted diagnosis, computer assisted tomography, disease course, echography, element analysis, female, finite, human, male, mechanical stress, methodology, middle aged, prediction and forecasting, prognosis, radiography, reproducibility, risk assessment, risk factor, three dimensional imaging, time
Persistent URL dx.doi.org/10.1016/j.ejvs.2010.02.017, hdl.handle.net/1765/20646
Journal European Journal of Vascular and Endovascular Surgery
Helderman, F, Manoch, I.J, Breeuwer, M, Kose, U, Boersma, H, van Sambeek, M.R.H.M, … Krams, R. (2010). Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms. European Journal of Vascular and Endovascular Surgery, 40(1), 47–53. doi:10.1016/j.ejvs.2010.02.017