AIMS To assess the effectiveness of antibiotics in acute bacterial sinusitis. METHODS This was a prospective cohort study with 2 months follow-up of 5640 patients with acute sinusitis included by a random sample from 1174 GPs and 120 ENT specialists. Main outcomes were short-term initial success, defined as the absence of prescription of (another) antibiotic or sinus lavage within 10 days, and lack of recurrence between the 11th and 60th day, after initial success. RESULTS Initial success was found in 88.7% (95% CI 85.1, 91.4%) of patients without antibiotic prescription at inclusion and 96.2% (95% CI 95.7, 96.7%) of patients prescribed antibiotics. The 10 day adjusted hazard ratio (HR) for treatment failure (new antibiotic prescription or sinus drainage) with initial antibiotics compared with no antibiotics was 0.30 (95% CI 0.21, 0.42) with no difference between antibiotics. Antibiotics were more effective in patients with poor oro-dental condition (HR 0.04, 95% CI 0.01, 0.20) and in patients who had already used antibiotics during the previous 2 months (HR 0.09, 95% CI 0.03, 0.28). For patients without failure at 10 days, recurrence between the 11th and 60th day was similar whether or not they had initially been prescribed an antibiotic, 94.1% (95% CI 93.4, 94.7%) and 93.4% (95%CI 90.3, 95.5%), respectively. CONCLUSION Most acute sinusitis cases not prescribed antibiotics resolve spontaneously. Antibiotics reduced by 3.3-fold the risk of failure within 10 days, without impact on later recurrence. The greatest benefit of antibiotics was found for patients with poor oro-dental condition or with antibiotic use within the previous 2 months.

Acute sunisitis, Antibiotics, Cohort study, Effectiveness, Pharmacoepidemiology, acute sinusitis, adult, amoxicillin, amoxicillin plus clavulanic acid, antibiotic agent, article, bacterial sinusitis, cefixime, cefotiam, cefpodoxime, ciprofloxacin, clarithromycin, clinical trial, cohort analysis, controlled clinical trial, controlled study, disease duration, drug efficacy, female, follow up, general practitioner, human, lavage, levofloxacin, major clinical study, male, medical practice, moxifloxacin, otorhinolaryngology, prescription, priority journal, pristinamycin, prospective study, randomized controlled trial, recurrent disease, telithromycin, treatment failure, treatment outcome,
British Journal of Clinical Pharmacology
Erasmus MC: University Medical Center Rotterdam

Blin, P, Blazejewski, S, Lignot, S, Lassalle, R, Bernard, M-A, Jayles, D, … Moore, N. (2010). Effectiveness of antibiotics for acute sinusitis in real-life medical practice. British Journal of Clinical Pharmacology, 70(3), 418–428. doi:10.1111/j.1365-2125.2010.03710.x