To determine the early and long-term morbidity of patients treated with a total laryngopharyngectomy and reconstruction using a jejunum interposition or gastric pull-up procedure. It is a retrospective study; and it is conducted in tertiairy referral center. Sixty-three patients were included in whom 70 reconstructions were performed (51 jejunum interpositions and 19 gastric pull-up procedures) between 1990 and 2007. The studied parameters were success rate of the reconstruction, early and long-term complication rate, and functional outcome including quality of life. Subjective quality of life analysis was determined by two questionnaires: the EORTC Quality of Life Questionnaire (QLQ)-C30 Dutch version 3.0, and the EORTC-Head and Neck (H & N 35). The success rates were 84 and 74%, respectively. The procedures were associated with a high complication rate (63% after jejunum interposition and 89% after gastric pull-up), and a lengthy rehabilitation. Surviving patients were found to have a good long-term quality of life. Complete oral intake was achieved in 97%, and speech rehabilitation in 95%. These procedures are associated with significant morbidity, high complication rates, lengthy rehabilitation, but a good long-term quality of life.

Functional results, Gastric pull-up, Horner syndrome, Jejunum interposition, Laryngopharyngectomy, Reconstruction, adult, aged, anastomosis dehiscence, article, cancer staging, cholecystitis, controlled study, depression, ear nose throat surgery, female, fistula, graft failure, hemiparesis, human, hypopharyngectomy, ileus, jejunum interposition, major clinical study, male, mediastinitis, morbidity, mortality, operation, overall survival, peritonitis, pneumonia, postoperative hemorrhage, primary tumor, priority journal, pull through, quality of life, questionnaire; respiratory failure, retrospective study, seizure, sepsis, speech rehabilitation, stomach spasm, tertiary health care, tracheitis, treatment outcome, tumor recurrence, wound dehiscence,
European Archives of Oto-Rhino-Laryngology
Erasmus MC: University Medical Center Rotterdam

Keereweer, S, de Wilt, J.H.W, Sewnaik, A, Meeuwis, C.A, Tilanus, H.W, & Kerrebijn, J.D.F. (2010). Early and long-term morbidity after total laryngopharyngectomy. European Archives of Oto-Rhino-Laryngology, 267(9), 1437–1444. doi:10.1007/s00405-010-1244-9