MS is a chronic disease affecting the CNS with an average disease onset in the third or fourth decade of life. Clinical symptoms are caused by changes in the motor, sensory, visual, and autonomic systems. Most common symptoms include visual and balance disturbances, spasticity, bladder dysfunction, pain, and fatigue. At a later disease stage, paralysis may occur. Other symptoms are Lhermitte’s symptom, an electrical sensation running down the spine or limbs when the neck bends, and Uhthoff phenomenon, worsening of symptoms when the core body temperature increases.

Additional Metadata
Keywords MS, experimental autoimmune encephalomyelitis, marmoset, multiple sclerosis
Publisher Erasmus University Rotterdam
Sponsor Erasmus MC Rotterdam, Biomedical Primate Research Centre, J.E. Jurriaanse Stichting, Remmert Adriaan Laan Fonds, U-CyTech Biosciences.
ISBN 978-90-73436-92-3
Persistent URL
Kap, Y.S. (2010, October 6). A Primate View on Multiple Sclerosis. Erasmus University Rotterdam. Retrieved from