Intermittent claudication is one of the clinical manifestations of obstructive disease of peripheral arteries of the lower extremities. The symptoms may include pain, cramp, and fatigue in the muscles of the affected leg provoked by exercise, which are relieved after several minutes of rest. These symptoms are caused by encroachment of the lumen by atherosclerosis, preventing an adequate supply of oxygen saturated blood. More severe manifestations are night- or restpain, and ulceration or gangrene of the toes or foot.

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Netherlands Heart Foundation, Interuniversity Cardiology Institute of the Netherlands
G.P. Krestin (Gabriel)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam