The paraganglion system is composed of a collection of chromaffin cells that is distributed throughout the body. Embryonically, chromaffin cells arise from the neuroectodermal tissue of the neural crest and are thought to migrate along the innervating nerves or vasculature towards their primordial location to form the paraganglia. The largest paraganglion is the adrenal medulla, an important neuroendocrine organ, which is the body’s main source of catecholamines (adrenalin, noradrenalin and dopamine). The adrenal medulla receives input from the sympathetic nervous system through preganglionic fibers upon which it releases its secretions directly into the blood. Besides this adrenal station there are many extra‐adrenal paraganglia that are distributed along the body axis and located in the proximity of ganglia of the sympathetic chain or in association with cranial nerves and blood vessels.

Additional Metadata
Keywords central nerve system, genes, neurology, paraganglion system
Promotor R.R. de Krijger (Ronald)
Publisher Erasmus University Rotterdam
Sponsor Erasmus MC Rotterdam, Pheo‐Para Alliance
Persistent URL
Gaal, J. (2010, November 10). Identifying Genes Involved in Paraganglioma Genesis. Erasmus University Rotterdam. Retrieved from