Intravascular ultrasound: validation and clinical application

Atherogenesis is a process with an insidious onset and course. Once clinical signs and symptoms have become manifest, the obstructive lesion is usually at an advanced stage. Arteriography is the standard method for evaluation of atherosclerotic disease and has been useful in identifying the location and approximate severity of the stenotic lesion. Although arteriography provides a silhouette of the vessel lumen, it does not provide accurate knowledge on cross-sectional lumen area, vessel area, shape and morphology of the stenotic lesion. Intravascular ultrasound (lVUS) may overcome these limitations by providing a tomographic image of the vessel. The aim of this work is to validate IVUS and to evaluate subsequent clinical application of this imaging technique. The subjects dealt with in this dissertation are categorised into 5 main topics. I) displacement sensing device; 2) validation of IVUS-derived parameters; 3) the spectrum of vascular morphology before and after intervention determined by IVUS; 4) IVUS as a research tool; 5) IVUS as a clinical tool

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