2010-11-23
Natriuretic Peptides, Diagnostic and Prognostic Biomarkers
Publication
Publication
Natriuretische peptiden, diagnostische en prognostische biomarkers
In humans, the natriuretic peptide family consists of three different types of peptides: atrial natriuretic peptide (synonym: atrial natriuretic factor), B-type natriuretic peptide (synonym: brain natriuretic peptide) and C-natriuretic peptide.1 Atrial natriuretic peptide (ANP) was the fi rst natriuretic peptide to be discovered and in humans ANP is predominantly formed in the cardiomyocytes of the atria.2 B-type natriuretic peptide (BNP) was fi rst discovered in porcine brain hence its original name brain natriuretic peptide.3 In humans, the majority of BNP is formed in ventricular cardiomyocytes, and mRNA levels in brain are negligible. Therefore, brain natriuretic peptide is now recognized as B-type natriuretic peptide. C-type natriuretic peptide (CNP) is basically a neuropeptide, found in brain and vascular endothelial cells.
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| The studies described in this thesis were fi nancially supported by a grantfrom the Erasmus MC Medical Research Advisory Committee (Mrace). TheNetherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD) wasfi nanced by the Dutch Kidney Foundation. The Rotterdam Study is supportedby the Erasmus MC and Erasmus University Rotterdam, the NetherlandsOrganization for Scientifi c Research (NWO), the Netherlands Organizationfor Health Research and Development (ZonMw), the Research Institute forDiseases in the Elderly (RIDE), the Ministry of Education, Culture and Science,the Ministry of Health, Welfare and Sport, the European Commission(DG XII), and the Municipality of Rotterdam. Roche Diagnostics Nederland BVprovided the assays for the measurement of NT-proBNP in the participants ofthe Rotterdam study at a reduced rate. | |
| A.H.J. Danser (Jan) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/21416 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Rutten, J. (2010, November 23). Natriuretic Peptides, Diagnostic and Prognostic Biomarkers. Retrieved from http://hdl.handle.net/1765/21416 |
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| Additional Files | |
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| stellingen_jhwrutten.pdf , 56kb | |
| 3200_Rutten, Joseph Henricus Wilhelmus.jpg Cover Image , 24kb | |
