The human body has an extensive and specialized cellular network to defend against invading microorganisms, and to prevent the development and spread of neoplastic disease. The mononuclear phagocytic cells are important secretory cells that, through their receptors and secretory products, have a central and essential role in the initiation and maintenance of many immunologic and inflammatory processes. The secretory products are listed in Table l.1. The mononuclear phagocyte system [monocytes and macrophages (M.p)] is complex, representing a heterogeneous group of cells found in organs and tissues throughout the body. All these mononuclear phagocytic cells are derived from a stem cell in the bone marrow.

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I.L. Bonta
Erasmus University Rotterdam
AbbottB.V. Astra Pharmaceutica B.V Bio Rad Laboratories BV, Byk Nederland B.V., Sandoz B.V., Medgenix B.V
Erasmus MC: University Medical Center Rotterdam

Pruimboom, W.M. (1995, January 25). Eicosanoid and cytokine production by human peritoneal macrophages : characterization and modulation. Erasmus University Rotterdam. Retrieved from