1995-03-15
Regulation and modulation of the plasma fibrinogen level
Publication
Publication
Regulatie en modulatie van de fibrinogeen-waarden in plasma
Fibrinogen is a soluble plasma glycoprotein that, under normal circumstances, is present in human plasma at a concentration of 2-4 mg/ml (6-12 I'M). The plasma half-life is 3-4 days in humans and about 10-25 % of the total body fibrinogen is extravascularl. Fibrinogen is composed of two sets of three polypeptide chains (AOI, 86 . and 'Y) that are interconnected by disulphide bridges . The aminoterminal segments of all six chains form a central domain from which the AOI and 86 chains protrude. These aminotermini are the target of thrombin and small peptides (FPA and FP8) can be cleaved off.
| Additional Metadata | |
|---|---|
| , , | |
| Netherlands Heart Foundation, Sanofi-Winthrop V.O.F., TNO | |
| C. Kluft (Cornelius) , J.H.P. Wilson (Paul) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/21470 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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de Maat, M. (1995, March 15). Regulation and modulation of the plasma fibrinogen level. Retrieved from http://hdl.handle.net/1765/21470 |
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| Additional Files | |
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| stellingen de maat.pdf , 29kb | |
| 1084_MAAT, Monica Petronella Maria de.jpg Cover Image , 13kb | |
