Assessing pain intensity in (preverbal) children is more difficult than in adults. Tools to measure pain are being used as primary endpoints [e.g., pain intensity, time to first (rescue) analgesia, total analgesic consumption, adverse effects, and long-term effects] in studies on the effects of analgesic drugs. Here, we review current and promising new endpoints used in pediatric pain assessment studies.

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Keywords Assessment, Long-term outcome, Pain, Pharmacodynamics, Pharmacokinetics
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Journal European Journal of Clinical Pharmacology
Note Article in press - dd December 2010
van Dijk, M, Ceelie, I, & Tibboel, D. (2011). Endpoints in pediatric pain studies. European Journal of Clinical Pharmacology (Vol. 67). doi:10.1007/s00228-010-0947-6