The association between preconception dietary intake of the polyunsaturated fatty acids (LC-PUFAs) omega-6 and omega-3 and the E2 levels and IVF/intracytoplasmic sperm injection (ICSI) outcome were investigated in women in a prospective study. It revealed that high intakes of omega-3 LC-PUFA alpha-linolenic acid increase baseline E2, high intakes of eicosapentaenoic acid and docosahexaenoic acid reduce E2 response and the number of follicles after ovarian stimulation, and total omega-3 intake, in particular alpha-linolenic acid and docosahexaenoic acid, improve embryo morphology.

, ,
doi.org/10.1016/j.fertnstert.2010.11.021, hdl.handle.net/1765/21877
Fertility and Sterility
Erasmus MC: University Medical Center Rotterdam

Hammiche, F., Vujkovic, M., Wijburg, W., de Vries, J., Macklon, N., Laven, J., & Steegers-Theunissen, R. (2011). Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertility and Sterility, 95(5), 1820–1823. doi:10.1016/j.fertnstert.2010.11.021