Most patients with chronic ischemia and an implantable cardiac defibrillator (ICD) for primary prevention do not experience therapies for ventricular arrhythmias on follow-up. The present study aimed to identify independent clinical, electrocardiographic, and echocardiographic predictors of death and occurrence of ICD therapy in patients with chronic ischemic cardiomyopathy and ICD for primary prevention. A total of 424 patients with chronic ischemic cardiomyopathy, ejection fraction ≤35%, and New York Heart Association (NYHA) class <0.001) predicted the occurrence of ICD therapy on follow-up. In conclusion, in chronic ischemic patients with an ICD for primary prevention, the presence of diabetes, renal dysfunction, higher NYHA class, and impaired peri-infarct zone function were predictors of all-cause mortality. In contrast, only impaired peri-infarct zone function determined the occurrence of appropriate ICD therapy on follow-up.

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Persistent URL dx.doi.org/10.1016/j.amjcard.2010.07.029, hdl.handle.net/1765/21947
Journal The American Journal of Cardiology
Citation
Ng, A.C.T, Bertini, M, Borleffs, C.J.W, Delgado, V, Boersma, H, & Piers, S.R.D. (2010). Predictors of death and occurrence of appropriate implantable defibrillator therapies in patients with ischemic cardiomyopathy. The American Journal of Cardiology, 106(11), 1566–1573. doi:10.1016/j.amjcard.2010.07.029