After decades of phase III trials failing to demonstrate an impact on survival of various drugs in metastatic melanoma there are finally significant advances in systemic therapies for melanoma emerging. Novel ways to modulate the immune system by monoclonal antibodies as well as various signalling pathway inhibitors are responsible for creating a whole new therapeutic landscape. For the first time it is likely that a number of new drugs with completely different mechanisms of action will be approved in the near future. The imminent candidates are the anti-CTLA-4 antibody ipilimumab, and the highly selective BRAF inhibitor PLX4032. But in each class other molecules are under development with good perspectives. Various new combinations will have to be explored and it is reasonable to expect synergies between the different classes of drugs as well as between novel molecules within the same class of drugs. Here, an overview of current developments and the most important new drugs under consideration is provided.

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Keywords 5 (4 bromo 2 chloroanilino) 4 fluoro 1 methyl 1h benzimidazole 6 carbohydroxamic acid 2 hydroxyethyl ester, Adjuvant therapy, Anti-CTLA-4, BRAF inhibition, Drug development, Melanoma, Systemic therapy, adoptive immunotherapy, adoptive transfer, allovectin 7, alpha interferon, antineoplastic activity, antineoplastic agent, autoimmune disease, bevacizumab, bms 663513, brain metastasis, cancer chemotherapy, cancer immunotherapy, cancer staging, cancer survival, cancer vaccine, canvaxin, clinical trial, colitis, conditioning, conference paper, cyclophosphamide, cytotoxic T lymphocyte antigen 4 antibody, dacarbazine, dermatitis, diarrhea, drug dose escalation, drug efficacy, drug megadose, drug research, drug response, drug targeting, fatigue, fludarabine, fotomustine, gene mutation, glycoprotein gp 100, granulocyte macrophage colony stimulating factor, human, hypertransaminasemia, imatinib, immunomodulation, immunopathology, interleukin 2, ipilimumab, keratoacanthoma, melanoma, monoclonal antibody, mutational analysis, neutropenia, nilotinib, nonhuman, nonmyeloablative, oncolytic herpes virus, overall survival, paclitaxel, plx 4032, priority journal, programmed death 1 receptor monoclonal antibody, recombinant melanoma antigen 3 fusion protein, signal transduction, skin carcinogenesis, sorafenib, squamous cell carcinoma, survival time, tamoxifen, temozolomide, ticilimumab, unclassified drug, unindexed drug
Persistent URL dx.doi.org/10.1093/annonc/mdq364, hdl.handle.net/1765/22071
Journal Annals of Oncology
Citation
Eggermont, A.M.M. (2010). Advances in systemic treatment of melanoma. In Annals of Oncology (Vol. 21). doi:10.1093/annonc/mdq364