Treatment adherence therapy in people with psychotic disorders: randomised controlled trial
British Journal of Psychiatry , Volume 197 - Issue 6 p. 448- 455
Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. METHOD: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). RESULTS: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve. CONCLUSIONS: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission.
|psychiatry, psychotic disorders|
|ERIM Article Series (EAS)|
|British Journal of Psychiatry|
|Organisation||Erasmus Research Institute of Management|
Staring, A.B.P, Van Der Gaag, M, Koopmans, G.T, Selten, J.P, van Beveren, N.J.M, Hengeveld, M.W, … Mulder, C.L. (2010). Treatment adherence therapy in people with psychotic disorders: randomised controlled trial. British Journal of Psychiatry, 197(6), 448–455. doi:10.1192/bjp.bp.110.077289