OBJECTIVE: To study whether lower arterial oxygen saturation (SaO(2)) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter lesions and lacunar infarcts. METHODS: We measured SaO(2) twice with a pulse oximeter, assessed the presence of COPD, and performed MRI in 1077 non-demented people from a general population (aged 60-90 years). We rated periventricular white matter lesions (on a scale of 0-9) and approximated a total subcortical white matter lesion volume (range 0-29.5 ml). All analyses were adjusted for age and sex and additionally for hypertension, diabetes, body mass index, pack years smoked, cholesterol, haemoglobin, myocardial infarction, and left ventricular hypertrophy. RESULTS: Lower SaO(2) was independent of potential confounders associated with more severe periventricular white matter lesions (score increased by 0.12 per 1% decrease in SaO(2) (95% confidence interval 0.01 to 0.23)). Participants with COPD had more severe periventricular white matter lesions than those without (adjusted mean difference in score 0.70 (95% confidence interval 0.23 to 1.16)). Lower SaO(2) and COPD were not associated with subcortical white matter lesions or lacunar infarcts. CONCLUSION: Lower SaO(2) and COPD are associated with more severe periventricular white matter lesions.

Aged, Body Mass Index, Brain Infarction/*complications/*metabolism/pathology, Brain/blood supply/metabolism/pathology, Cholesterol/blood, Diabetes Mellitus/epidemiology, Female, Hemoglobins/metabolism, Humans, Hypertension/epidemiology, Hypertrophy, Left Ventricular/epidemiology/pathology, Magnetic Resonance Imaging, Male, Myocardial Infarction/epidemiology, Oximetry/methods, Oxygen/*metabolism, Pulmonary Disease, Chronic Obstructive/*complications/*metabolism, Smoking/epidemiology
dx.doi.org/10.1136/jnnp.2003.022012, hdl.handle.net/1765/22488
Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery
Erasmus MC: University Medical Center Rotterdam

van Dijk, E.J, Vermeer, S.E, de Groot, J.C, van de Minkelis, J, Prins, N.D, Oudkerk, M, … Breteler, M.M.B. (2004). Arterial oxygen saturation, COPD, and cerebral small vessel disease. Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, 75(5), 733–736. doi:10.1136/jnnp.2003.022012