1999-05-01
Secondary prevention after cerebral ischaemia of presumed arterial origin: is aspirin still the touchstone?
Publication
Publication
Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery , Volume 66 - Issue 5 p. 557- 559
Patients who have had a transient ischaemic attack or nondisabling ischaemic stroke of presumed arterial origin have an annual risk of death from all vascular causes, non-fatal stroke, or non-fatal myocardial infarction that ranges between 4% and 11% without treatment. In the secondary prevention of these vascular complications the use of aspirin has been the standard treatment for the past two decades. Discussions about the dose of aspirin have dominated the issue for some time, although there is no convincing evidence for any difference in effectiveness in the dose range of 30-1300 mg/day. A far greater problem is the limited degree of protection offered by aspirin: the accumulative evidence from trials with aspirin alone and only for cerebrovascular disease of presumed arterial origin as qualifying event indicates that a dose of aspirin of at least 30 mg/day prevents only 13% of serious vascular complications.
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| doi.org/10.1136/jnnp.66.5.557, hdl.handle.net/1765/22510 | |
| Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Algra, A., Koudstaal, P., & van Gijn, J. (1999). Secondary prevention after cerebral ischaemia of presumed arterial origin: is aspirin still the touchstone?. Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, 66(5), 557–559. doi:10.1136/jnnp.66.5.557 |
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