We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.

CaMKII, calcium signals, cerebellum, fiber-Purkinje cell synapse, plasticity, synaptic depression
dx.doi.org/10.1038/nn.2329, hdl.handle.net/1765/22573
Published online: 7 June 2009
Erasmus MC: University Medical Center Rotterdam

van Woerden, G.M, Hoebeek, F.E, Gao, Z, Nagaraja, R.Y, Hoogenraad, C.C, Kushner, S.A, … Elgersma, Y. (2009). βCaMKII controls the direction of plasticity at parallel fiber–Purkinje cell synapses. doi:10.1038/nn.2329