Biological research is impossible to imagine without a microscope. Latest genera- tions of microscopes, able to produce huge arrays of multidimensional data, only distantly resemble Leeuwenhoek’s first microscope. Every advance in visualization techniques and hardware brings us one step closer to understanding life, e.g., how genome information gives identity to cells, how cells constitute organisms and how errant cells cause disease. Discovery of the green fluorescent protein (GFP) in the nineties of the previous century was definitely one of the most impor- tant milestones on that path, giving new strong impulse to the field of fluorescence microscopy.

Erasmus MC Rotterdam,NWO
W.J. Niessen (Wiro)
Erasmus University Rotterdam
ASCI dissertation series
Erasmus MC: University Medical Center Rotterdam

Dzyubachyk, O. (2011, April 13). Model-Based Cell Tracking and Analysis in Fluorescence Microscopy (No. 231). ASCI dissertation series. Retrieved from