Influence of gender and menopausal status on antidepressant treatment response in depressed inpatients
Journal of Psychopharmacology , Volume 24 - Issue 4 p. 497- 502
Abstract: The present study investigated the influence of gender and menopausal status on treatment response in depressed inpatients, treated with either imipramine or fluvoxamine. The patients were divided into three groups: men, premenopausal women and postmenopausal women. A multivariate analysis was performed using the difference in Hamilton score (pretreatment - post-treatment) for imipramine and fluvoxamine as dependent variable. The following independent variables were used: the baseline Hamilton score, the antidepressant used, the gender-group and the interaction between the type of antidepressant and gender. In total, 138 patients with a DSM IV diagnosis of depressive disorder were analysed. Men responded more favorably to imipramine (B = 7.12, P = 0.005). Premenopausal women had a better response rate to fluvoxamine than men (B = -8.66, P = 0.027). In depressed inpatients, men respond more favorably to imipramine than to fluvoxamine. Premenopausal women respond more frequently to fluvoxamine than men.
|*Inpatients, Adult, Aged, Antidepressive Agents/*therapeutic use, Depressive Disorder/diagnosis/*drug therapy/psychology, Double-Blind Method, Female, Fluvoxamine/*therapeutic use, Humans, Imipramine/*therapeutic use, Linear Models, Male, Menopause/*psychology, Middle Aged, Netherlands, Psychiatric Status Rating Scales, Questionnaires, Sex Factors, Single-Blind Method, Treatment Outcome, Young Adult|
|Journal of Psychopharmacology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Vermeiden, M, van den Broek, W.W, Mulder, P.G.H, & Birkenhäger, T.K. (2010). Influence of gender and menopausal status on antidepressant treatment response in depressed inpatients. Journal of Psychopharmacology, 24(4), 497–502. doi:10.1177/0269881109105137