The syndromic primary immunodeficiencies are disorders in which not only the immune system but also other organ systems are affected. Other features most commonly involve the ectodermal, skeletal, nervous, and gastrointestinal systems. Key in identifying syndromic immunodeficiencies is the awareness that increased susceptibility to infections or immune dysregulation in a patient known to have other symptoms or special features may hint at an underlying genetic syndrome. Because the extraimmune clinical features can be highly variable, it is more difficult establishing the correct diagnosis. Nevertheless, correct diagnosis at an early age is important because of the possible treatment options. Therefore, diagnostic work-up is best performed in a center with extensive expertise in this field, having immunologists and clinical geneticists, as well as adequate support from a specialized laboratory at hand. This paper provides the general pediatrician with the main clinical features that are crucial for the recognition of these syndromes.

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Keywords 22q11 deletion syndrome, DNA repair disorders, Genetics, Primary immunodeficiency, Syndromic immunodeficiency
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Journal European Journal of Pediatrics
Kersseboom, R, Brooks, A.S, & Weemaes, C.M.R. (2011). Educational paper - Syndromic forms of primary immunodeficiency. European Journal of Pediatrics (Vol. 170, pp. 295–308). doi:10.1007/s00431-011-1396-7