Unraveling Mill-Rearranged Pedriatic Acute Myeloid Leukemia
Het ontrafelen van acute myeloïde leukemie met een MLL-gen herschikking in kinderen
Blood cells are derived from hematopoietic stem cells (HSC) that reside in the bone marrow. HSC’s are multipotent and have the capacity to diff erentiate into the cells of all blood lineages, i.e. erythrocytes, platelets, neutrophils, eosinophils, basophils, monocytes, T and B lymphocytes, natural killer cells, and dendritic cells. Leukemia is cancer of the blood in which the normal population of blood cells in the bone marrow is replaced by immature blood cells (blasts). Th ese immature cells occur due to an imbalance in diff erentiation and proliferation. Accumulation of these malignant cells in the bone marrow results in decrease of normal mature blood cells, like white blood and red blood cells and platelets.
|Keywords||acute myeloid leukemia, blood cells, cancer, hematology|
|Promotor||R. Pieters (Rob)|
|Publisher||Erasmus University Rotterdam|
|Sponsor||NWO,Novartis,Genzyme,MRC-Holland BV,Pediatric Oncology Foundation Rotterdam|
Balgobind, B.V. (2011, May 25). Unraveling Mill-Rearranged Pedriatic Acute Myeloid Leukemia. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/23424