Infertility, defined as the inability to conceive spontaneously within one year, is a common medical problem. Traditionally, fertility investigations initially focus on the evaluation of ovulation and tubal patency in females, and on assessment of sperm quantity and quality in males. In about one third of couples with infertility abnormalities in classic semen parameters are found, like sperm concentration, motility and morphology. In another one third of patients a combination of infertility-related female and male factors are seen (WHO 1999). Although sperm quality parameters derived from classic semen analysis are frequently used to categorise male infertile patients, the prognostic and diagnostic information they provide is limited with a predictive power that is highest at the lower ranges of the spectrum (Barratt et al. 2010).

Additional Metadata
Keywords DNA damage, andrology, male infertility, sperm chromatin structure
Promotor C.H. Bangma (Chris)
Publisher Erasmus University Rotterdam
ISBN 978-94-6169-024-1
Persistent URL
Smit, M. (2011, March 30). Clinical Application of Sperm Chromatin Structure Assessment in Andrology Patients. Erasmus University Rotterdam. Retrieved from