The documented history of allogeneic cardiac valve implantation began in 1952. In that year, the first successful implantation of an canine aortic valve in the descendlng aorta of another dog, was carried out by Conrad Lam etal. Driven by the succes seen in this animal model Murray et al. started to insert fresh human aortic valves in the descending aorta of patients with severe aonic insufficiency in 1956. The function of these valves was reported to be satisfactory for up to 6 years. After the introduction of open heart surgery around 1962, the replacement of aortic valve by inserting an aortic allograft into the subcoronary position was proposed by Duran et al. and completed with clinical success by Ross et al. In that same petiod, Barratt-Boyes et al. from Auckland, New Zealand reported that they also started to insert aortic valve allografts in the subcoronary position independently from the London group.

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A.J.J.C. Bogers (Ad) , W. Weimar (Willem)
Erasmus University Rotterdam
Netherlands Heart Foundation
Erasmus MC: University Medical Center Rotterdam

Oei, F.B.S. (2001, November 14). Immunological aspects of clinical and experimental cardiac valve allograft implantation. Erasmus University Rotterdam. Retrieved from