2011-06-15
Improvement of Thymopoiesis after Hematopoietic Stem Cell Transplantation by Cytokines: Translational studies in experimental animal models
Publication
Publication
Optimalisatie van thymopoiese na hematopoietische stamceltransplantatie: Translationele studies met cytokines in experimentele diermodellen
Allogeneic hematopoietic stem cell transplantation (AlloHSCT) is a powerful treatment modality that is frequently applied as part of treatment of hematological malignancies, aplastic anemia and inborn errors of hematopoietic progenitor cells. A major drawback of alloHSCT is the treatment related morbidity and treatment related mortality (TRM), which are largely accounted for by opportunistic infections. Those infections occur during a prolonged period (1-2 years), characterized by an impaired reconstitution of the adaptive immune system. Especially, the recovery of naïve T cells and thymopoiesis are protracted after transplantation, but are considered pivotal for restoration of anti-infectious immunity. This thesis has experimentally addressed new strategies that may improve thymopoiesis, including the post-transplant administration of cytokines that are physiologically involved in the differentiation and proliferation of thymocytes.
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, , , | |
Dutch Cancer Society (KWF) | |
Erasmus MC: University Medical Center Rotterdam | |
J.J. Cornelissen (Jan) | |
hdl.handle.net/1765/23627 | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Wils, E.-J. (2011, June 15). Improvement of Thymopoiesis after Hematopoietic Stem Cell Transplantation by Cytokines: Translational studies in experimental animal models. Retrieved from http://hdl.handle.net/1765/23627 |
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cover dissertatie E-J Wils juni 2011.pdf , 1mb | |
Stellingen dissertatie E-J Wils 15 juni 2011.pdf , 177kb | |
3330_Wils, Evert-Jan.jpg Cover Image , 37kb |