Low serum concentrations of micronutrients, intestinal abnormalities, and an inflammatory state have been associated with HIV progression. These may be ameliorated by micronutrients, N-acetyl cysteine, probiotics, and prebiotics. This review aims to integrate the evidence from clinical trials of these interventions on the progression of HIV. Vitamin B, C, E, and folic acid have been shown to delay the progression of HIV. Supplementation with selenium, N-acetyl cysteine, probiotics, and prebiotics has considerable potential, but the evidence needs to be further substantiated. Vitamin A, iron, and zinc have been associated with adverse effects and caution is warranted for their use.

AIDS, CD4 lymphocyte count, HIV, Human immunodeficiency virus infection, Micronutrients, N-acetyl cysteine, Pneumocystis pneumonia, Prebiotics, Probiotics, Selenium, Zinc, acetylcysteine, alpha tocopherol, anemia, ascorbic acid, beta carotene, cell activity, dapsone, deferoxamine, disease course, disease transmission, drug megadose, folic acid, follow up, glutathione, human, infection risk, iron, iron deficiency, low birth weight, low drug dose, mortality, multivitamin, natural killer cell, nutritional status, outcome assessment, overall survival, placebo, prebiotic agent, pregnancy outcome, premature labor, probiotic agent, randomized controlled trial (topic), retinol, retinol deficiency, review, risk reduction, selenium, survival time, trace element, treatment duration, treatment outcome, vertical transmission, virus infectivity, virus load, vitamin B group, vitamin D, vitamin supplementation, zinc, zinc deficiency
dx.doi.org/10.3390/nu2060626, hdl.handle.net/1765/23796
Erasmus MC: University Medical Center Rotterdam

Hummelen, R.B.S, Hemsworth, J, & Reid, G.K. (2010). Micronutrients, N-acetyl cysteine, probiotics and prebiotics, a review of effectiveness in reducing HIV progression. Nutrients, 2(6), 626–651. doi:10.3390/nu2060626