We have introduced a mouse Thy-1.1 gene into the germline of Thy-1.2 mice. The introduced gene was shown to be expressed at very high levels in thymocytes when compared with the endogenous gene. Transgenic thymocytes were shown to evoke a higher than normal primary anti-Thy-1.1 antibody response in plaque-forming cell (PFC) assays. This result suggests that a direct quantitative interaction of the Thy-1 antigen activates the B cell response.

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Journal of Immunology
Erasmus MC: University Medical Center Rotterdam

Isobe, K-I, Kollias, G, Kolsto, A-B, & Grosveld, F.G. (1986). T-cell independent Thy-1 allo-antibody response with the use of transgenic mice. Journal of Immunology, 137, 2089–2092. Retrieved from http://hdl.handle.net/1765/2404