The DNA spanning two large deletions in the human beta-globin gene cluster (gamma beta-thalassaemia 1 and 2) has been cloned by cosmid cloning and chromosomal walking. The entire region was mapped and analyzed for the presence of repetitive sequences. The results show that the affected loci have lost almost 100 kb of DNA in a deletion event not involving homologous or repetitive sequences.

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Nucleic Acids Research
Erasmus MC: University Medical Center Rotterdam

Taramelli, R., Kioussis, D., Vanin, E., Bartram, K., Groffen, J., Hurst, J., & Grosveld, F. (1986). γδβ-thalassaemias 1 and 2 are the result of a 100 kpb deletion in the human β-globin cluster. Nucleic Acids Research, 14, 7017–7028. Retrieved from