Cushing syndrome as the presenting symptom of a malignant renal tumor in children is rare. We report the first case of paraneoplastic Cushing syndrome due to a Wilms tumor, in which clinical and biological signs of hypercortisolism regressed during preoperative chemotherapy. Additionally, we reviewed the literature on paraneoplastic Cushing syndrome secondary to pediatric renal tumors.

Adrenocorticotropic hormone (ACTH), Corticotrophin-releasing hormone (CRH), Cushing syndrome, Nephroblastoma, Renal tumor
dx.doi.org/10.1002/pbc.22021, hdl.handle.net/1765/24111
Pediatric Blood & Cancer
Erasmus MC: University Medical Center Rotterdam

Segers, H, van der Heyden, J.C, van den Akker, E.L.T, de Krijger, R.R, Zwaan, C.M, & van den Heuvel-Eibrink, M.M. (2009). Cushing syndrome as a presenting symptom of renal tumors in children. Pediatric Blood & Cancer, 53(2), 211–213. doi:10.1002/pbc.22021