We sought to investigate the performance of 64-slice CT in symptomatic patients with different coronary calcium scores. Two hundred patients undergoing 64-slice CT coronary angiography for suspected coronary artery disease were enrolled into five groups based on Agatston calcium score using the Mayo Clinic risk stratification: group 1: score 0, group 2: score 1-10, group 3: score 11-100, group 4: score 101-400, and group 5: score > 401. Diagnostic accuracy for the detection of significant (≥50% lumen reduction) coronary artery stenosis was assessed on a per-segment and per-patient base using quantitative coronary angiography as the gold standard. For groups 1 through 5, sensitivity was 97, 96, 91, 90, 92%, and specificity was 99, 98, 96, 88, 90%, respectively, on a per-segment basis. On a per-patient basis, the best diagnostic performance was obtained in group 1 (sensitivity 100% and specificity 100%) and group 5 (sensitivity 95% and specificity 100%). Progressively higher coronary calcium levels affect diagnostic accuracy of CT coronary angiography, decreasing sensitivity and specificity on a per-segment base. On a per-patient base, the best results in terms of diagnostic accuracy were obtained in the populations with very low and very high cardiovascular risk.

Additional Metadata
Keywords Calcium score, Cardiovascular risk, Coronary angiography, Mayo Clinic classification, Multislice computed tomography
Persistent URL dx.doi.org/10.1007/s00330-009-1398-2, hdl.handle.net/1765/24171
Journal European Radiology: journal of the European Congress of Radiology
Palumbo, A.A, Maffei, E, Martini, C, Tarantini, G, di Tanna, G.L, Berti, E, … Cademartiri, F. (2009). Coronary calcium score as gatekeeper for 64-slice computed tomography coronary angiography in patients with chest pain: Per-segment and per-patient analysis. European Radiology: journal of the European Congress of Radiology, 19(9), 2127–2135. doi:10.1007/s00330-009-1398-2