Total mesorectal excision for rectal cancer in an unselected population: Quality assessment in a low volume center
International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery , Volume 24 - Issue 8 p. 923- 929
Objective: The aim of this study was to review the results and long-term outcome after total mesorectal excision (TME) for adenocarcinoma of the rectum in an unselected population in a community teaching hospital. Materials and methods: Between 1996 and 2003, 210 patients with rectal cancer were identified in our prospective database, containing patient characteristics, radiotherapy plans, operation notes, histopathological reports, and follow-up details. An evaluation of prognostic factors for local recurrence, distant metastases, and overall survival was performed. Results: The mean age at diagnosis was 69 years (range 40-91 years). A total of 145 patients were treated by anterior rectal resection; 65 patients had to undergo an abdominoperineal resection (APR). Anastomotic leakage rate was 5%. Postoperative mortality was 3%. After a median follow-up of 3.6 years, the local recurrence-free rate in patients with microscopically complete resections was 91%. The 5-year overall survival rate was 58%. An increased serum carcinoembryonic antigen, an APR, positive lymph nodes, and an incomplete resection all significantly influenced the 5-year overall survival and local recurrence rate. In a multivariate analysis, age was the most important prognostic factor for overall survival. Conclusions: Patients with rectal cancer can safely be treated with TME in a community teaching hospital and leads to a good overall survival and an excellent local control. In patients aged above 80, treatment-related mortality is an important competitive risk factor, which obscures the positive effect of modern rectal cancer treatment.
|CEA, Carcinoma, Local recurrence, Radiotherapy, Rectal cancer, TME|
|International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Ferenschild, F.T.J, Dawson, I, de Wilt, J.H.W, de Graaf, E.J.R, Groenendijk, R.P.R, & Tetteroo, G.W.M. (2009). Total mesorectal excision for rectal cancer in an unselected population: Quality assessment in a low volume center. International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery, 24(8), 923–929. doi:10.1007/s00384-009-0732-0