We have defined DNA repeat variability in the 3?-terminus of the cagA gene of Helicobacter pylori strains from Malaysian patients of different ethnicities. We identified different alleles based on the EPIYA repeats. cagA types A-B-D and A-B-B-D are more similar to the sequence of Japanese strains, whereas cagA types A-B-C, A-B-C-C, A-B and A-C displayed similarity to strain 26695 sequences. A significant association was found between cagA genotypes and patients' ethnicity, with cagA type A-B-D being predominantly isolated from Chinese patients and cagA type A-B-C from Malays and Indians. Our data further corroborate the possibility that variant biological activity of CagA may affect the host specificity and/or pathogenicity of H. pylori.

dx.doi.org/10.1007/s10096-009-0712-x, hdl.handle.net/1765/24195
European Journal of Clinical Microbiology & Infectious Diseases: an international journal on pathogenesis, diagnosis, epidemiology, therapy, and prevention of infectious diseases
Erasmus MC: University Medical Center Rotterdam

Mohamed, R, Hanafiah, A, Rose, I.M, Manaf, M.R.A, Abdullah, S.A, Sagap, I, … Yaacob, J.A. (2009). Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. European Journal of Clinical Microbiology & Infectious Diseases: an international journal on pathogenesis, diagnosis, epidemiology, therapy, and prevention of infectious diseases, 28(7), 865–869. doi:10.1007/s10096-009-0712-x