Background & aims: Nutritional support improves outcome in critically ill infants but is impeded by fluid restriction, gastric intolerance and feeding interruptions. Protein and energy-enriched infant formulas may help to achieve nutritional targets earlier during admission and promote anabolism. Methods: Randomized controlled design. Infants with respiratory failure due to RSV-bronchiolitis received a protein and energy-enriched formula (PE-formula, n = 8) or a standard formula (S-formula, n = 10) during 5 days after admission. Primary outcome: nutrient delivery, energy and nitrogen balance and plasma amino acid concentrations. Secondary outcome: tolerance and safety. Results: Nutrient intakes were higher in PE fed infants and met population reference intake (PRI) on day 3-5 whilst in S-fed infants PRI was met on day 5 only. Cumulative nitrogen balance (cNB) and energy balance (cEB) were higher in PE-infants compared to S-infants (cNB: 866 ± 113 vs. 296 ± 71 mg/kg; cEB: 151 ± 31 and 26 ± 17 kcal/kg, both P < 0.01). Essential amino acid levels were higher in PE-infants but within reference limits whereas below these limits in S-infants. Both formulas were well tolerated. Conclusions: Early administration of a protein and energy-enriched formula in critically ill infants is well tolerated, promotes a more adequate nutrient intake and improves energy and nitrogen balance without adverse effects.

Nitrogen balance, Nutritional support, Requirements, Tolerance,
Clinical Nutrition
Erasmus MC: University Medical Center Rotterdam

van Waardenburg, D.A, de Betue, C.T, van Goudoever, J.B, Zimmermann, L.J.I, & Joosten, K.F.M. (2009). Critically ill infants benefit from early administration of protein and energy-enriched formula: A randomized controlled trial. Clinical Nutrition, 28(3), 249–255. doi:10.1016/j.clnu.2009.03.005