2009-08-01
Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry
Publication
Publication
Nature Genetics , Volume 41 - Issue 8 p. 879- 881
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10-11; combined RR = 1.25; combined P = 1.8 × 10-15).
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| doi.org/10.1038/ng.416, hdl.handle.net/1765/24581 | |
| Nature Genetics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Benjamin, E., Rice, K., Arking, D., Pfeufer, A., van Noord, C., Smith, A. V., Schnabel, R., Bis, J., Boerwinkle, E., Sinner, M., Dehghan, A., Lubitz, S., D'Agostino, R., Lumley, T., Ehret, G., Heeringa, J., Aspelund, T., Newton-Cheh, C., Larson, M., … Witteman, J. (2009). Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. Nature Genetics, 41(8), 879–881.https://doi.org/10.1038/ng.416 |
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