Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

doi.org/10.1086/644739, hdl.handle.net/1765/24628
Clinical Infectious Diseases
Erasmus MC: University Medical Center Rotterdam

de Pagter, A., Haveman, L., Schuurman, R., Schutten, M., Bierings, M., & Boelens, J. (2009). Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: A very strong risk factor for adenovirus DNAemia in pediatric patients. Clinical Infectious Diseases, 49(10), 1536–1539. doi:10.1086/644739