Gene-environment interactions in Leber hereditary optic neuropathy
Brain: a journal of neurology , Volume 132 - Issue 9 p. 2317- 2326
Leber hereditary optic neuropathy (LHON) is a genetic disorder primarily due to mutations of mitochondrial DNA (mtDNA). Environmental factors are thought to precipitate the visual failure and explain the marked incomplete penetrance of LHON, but previous small studies have failed to confirm this to be the case. LHON has no treatment, so identifying environmental triggers is the key to disease prevention, whilst potentially revealing new mechanisms amenable to therapeutic manipulation. To address this issue, we conducted a large, multicentre epidemiological study of 196 affected and 206 unaffected carriers from 125 LHON pedigrees known to harbour one of the three primary pathogenic mtDNA mutations: m.3460G>A, m.11778G>A and m.14484T>C. A comprehensive history of exposure to smoking, alcohol and other putative environmental insults was collected using a structured questionnaire. We identified a strong and consistent association between visual loss and smoking, independent of gender and alcohol intake, leading to a clinical penetrance of 93 in men who smoked. There was a trend towards increased visual failure with alcohol, but only with a heavy intake. Based on these findings, asymptomatic carriers of a LHON mtDNA mutation should be strongly advised not to smoke and to moderate their alcohol intake.
|Alcohol, Epigenetics, Leber hereditary optic neuropathy, Mitochondrial DNA, Tobacco|
|Brain: a journal of neurology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Kirkman, M.A, Yu-Wai-Man, P, Korsten, A, Leonhardt, M, Dimitriadis, K, de Coo, I.F.M, … Chinnery, P.F. (2009). Gene-environment interactions in Leber hereditary optic neuropathy. Brain: a journal of neurology, 132(9), 2317–2326. doi:10.1093/brain/awp158