2009
Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in β-blocker users
Publication
Publication
Clinical Pharmacology and Therapeutics , Volume 85 - Issue 1 p. 45- 50
Several β-blockers are metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6*4 is the main polymorphism leading to decreased enzyme activity. The clinical significance of impaired elimination of β-blockers is controversial, and most studies suffer from inclusion of small numbers of poor metabolizers (PMs) of CYP2D6. In this study, the association between CYP2D6*4 and blood pressure or heart rate was examined in 1,533 users of β-blockers in the Rotterdam Study, a population-based cohort study. In CYP2D6 *4/*4 PMs, the adjusted heart rate in metoprolol users was 8.5 beats/min lower compared with *1/*1 extensive metabolizers (EMs) (P < 0.001), leading to an increased risk of bradycardia in PMs (odds ratio = 3.86; 95% confidence interval 1.68-8.86; P = 0.0014). The diastolic blood pressure in PMs was 5.4 mm Hg lower in users of β-blockers metabolized by CYP2D6 (P = 0.017) and 4.8 mm Hg lower in metoprolol users (P = 0.045) compared with EMs. PMs are at increased risk of bradycardia.
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| doi.org/10.1038/clpt.2008.172, hdl.handle.net/1765/25062 | |
| Clinical Pharmacology and Therapeutics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Bijl, M., Visser, L., van Schaik, R., Kors, J., Witteman, J., Hofman, A., … Stricker, B. (2009). Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in β-blocker users. Clinical Pharmacology and Therapeutics, 85(1), 45–50. doi:10.1038/clpt.2008.172 |
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