The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

0 (Myelin P0 Protein), 0 (Myelin Proteins), 0 (Transcription Factors), 132052-52-9 (POU transcription factor Oct-6), Animals, Animals, Newborn, Axons/ultrastructure, Base Sequence, Cell Differentiation, Gene Expression, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Myelin P0 Protein/genetics/metabolism, Myelin Proteins/genetics/metabolism, Myelin Sheath/physiology, Recombination, Genetic, Schwann Cells/*cytology/physiology, Sciatic Nerve/cytology/growth & development, Stem Cells, Transcription Factors/*genetics/*physiology
Erasmus MC: University Medical Center Rotterdam

Jaegle, M.M, Mandemakers, W.J, Broos, L.A.M, Zwart, R, Karis, A, Visser, P, … Meijer, D.N. (1996). The POU factor Oct-6 is required for the progression of Schwann cell differentiation in peripheral nerves. Science, 273(5274), 507–510. Retrieved from