The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

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hdl.handle.net/1765/2529
Science
Erasmus MC: University Medical Center Rotterdam

Jaegle, M., Mandemakers, W., Broos, L., Zwart, R., Karis, A., Visser, P., … Meijer, D. (1996). The POU factor Oct-6 is required for the progression of Schwann cell differentiation in peripheral nerves. Science, 273(5274), 507–510. Retrieved from http://hdl.handle.net/1765/2529