Background: Computerised cognitive-behavioural therapy (CCBT) might offer a solution to the current undertreatment of depression. Aims: To determine the clinical effectiveness of online, unsupported CCBT for depression in primary care. Method: Three hundred and three people with depression were randomly allocated to one of three groups: Colour Your Life; treatment as usual (TAU) by a general practitioner; or Colour Your Life and TAU combined. Colour Your Life is an online, multimedia, interactive CCBT programme. No assistance was offered. We had a 6-month follow-up period. Results: No significant differences in outcome between the three interventions were found in the intention-to-treat and per protocol analyses. Conclusions: Online, unsupported CCBT did not outperform usual care, and the combination of both did not have additional effects. Decrease in depressive symptoms in people with moderate to severe depression was moderate in all three interventions. Online CCBT without support is not beneficial for all individuals with depression.,
British Journal of Psychiatry
Erasmus MC: University Medical Center Rotterdam

de Graaf, E., Gerhards, S., Arntz, A., Riper, H., Metsemakers, J., Evers, S., … Huibers, M. (2009). Clinical effectiveness of online computerised cognitive-behavioural therapy without support for depression in primary care: Randomised trial. British Journal of Psychiatry, 195(1), 73–80. doi:10.1192/bjp.bp.108.054429