Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+and CD34+cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

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doi.org/10.3324/haematol.2008.000034, hdl.handle.net/1765/25438
Erasmus MC: University Medical Center Rotterdam

Heringer-Walther, S, Eckert, K, Schumacher, S.M, Uharek, L, Wulf-Goldenberg, A, Gembardt, F, … Walther, T. (2009). Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo. Haematologica, 94(6), 857–860. doi:10.3324/haematol.2008.000034