2011-05-01
Educational paper: The expanding clinical and immunological spectrum of severe combined immunodeficiency
Publication
Publication
European Journal of Pediatrics , Volume 170 - Issue 5 p. 561- 571
Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency characterized by absence of functional T lymphocytes. It is a paediatric emergency, which is life-threatening when recognized too late. The clinical presentation varies from the classical form of SCID through atypical SCID to Omenn syndrome. In addition, there is a considerable immunological variation, which can hamper the diagnosis. In this educational review, we describe the immunopathological background, clinical presentations and diagnostic process of SCID, as well as the therapeutic possibilities.
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| doi.org/10.1007/s00431-011-1452-3, hdl.handle.net/1765/25490 | |
| European Journal of Pediatrics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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van der Burg, M., & Gennery, A. R. (2011). Educational paper: The expanding clinical and immunological spectrum of severe combined immunodeficiency. European Journal of Pediatrics (Vol. 170, pp. 561–571). doi:10.1007/s00431-011-1452-3 |
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