On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.

*Locus Control Region, Animals, Chromosomes, Gene Deletion, Gene Transfer Techniques, Globins/*genetics, Humans, Thalassemia/genetics, Transgenes
dx.doi.org/10.1016/S0959-437X(99)80023-9, hdl.handle.net/1765/2566
Current Opinion in Genetics & Development
Erasmus MC: University Medical Center Rotterdam

Grosveld, F.G. (1999). Activation by Locus Control Regions?. Current Opinion in Genetics & Development (Vol. 9, pp. 152–157). doi:10.1016/S0959-437X(99)80023-9