Assessment of problematic severe asthma in children should be performed in a stepwise manner to ensure an optimal approach. A four-step assessment scheme is proposed. First, a full diagnostic work-up is performed to exclude other diseases which mimic asthma. Secondly, a multi-disciplinary assessment is performed to identify issues that may need attention, including comorbidities. Thirdly, the pattern of inflammation is assessed, and finally steroid responsiveness is documented. Based upon these four steps an optimal individualised treatment plan is developed. In this article the many gaps in our current knowledge in all these steps are highlighted, and recommendations for current clinical practice and future research are made. The lack of good data and the heterogeneity of problematic severe asthma still limit our ability to optimise the management on an individual basis in this small, but challenging group of patients. Copyright

Asthma, Child, Diagnostics, Severe
dx.doi.org/10.1183/09031936.00091410, hdl.handle.net/1765/26032
The European Respiratory Journal
Erasmus MC: University Medical Center Rotterdam

Lødrup Carlsen, K.C, Hedlin, G, Bush, A, Wennergren, G, de Benedictis, F.M, de Jongste, J.C, … Carlsen, K.H. (2011). Assessment of problematic severe asthma in children. The European Respiratory Journal (Vol. 37, pp. 432–440). doi:10.1183/09031936.00091410