2011-12-01
Triple-negative breast cancer with brain metastases: a comparison between basal-like and non-basal-like biological subtypes
Publication
Publication
Journal of Neuro-Oncology , Volume 105 - Issue 3 p. 547- 553
The aim of this study was to divide the group of triple-negative breast cancer patients with brain metastases into basal-like and non-basal-like biological subtypes in order to compare clinical features and survival rates in those two groups. A comprehensive analysis of 111 consecutive triple-negative breast cancer patients with brain metastases treated in the years 2003-2009 was performed. In 75 patients, immunohistochemistry was used as a surrogate of microarray in order to evaluate the expression of three basal markers: cytokeratin 5/6 (CK 5/6), EGFR/HER1 and c-KIT. The basal-like (ER/PgR/HER2-negative, CK5/6positive and/or HER1-positive) and non-basal-like (ER/PgR/HER2-negative, CK5/6-negative, HER1-negative) subsets were selected. Clinical features and survivals were compared in both groups. In the group of 111 triple-negative breast cancer patients, median DFS, OS and survival from brain metastases were 20, 29 and 4 months, respectively. In 75 patients who were evaluable for basal markers, median DFS, OS and survival from brain metastases were 18, 26 and 3.2 months, respectively. In the basal-like subtype, the survival rates were 15, 26 and 3 months, respectively, and in the non-basal-like subtypes, they were 20, 30 and 2.8 months, respectively. No statistically significant differences in survivals were detected between the basal-like and non-basal-like biological subtypes. Factors influencing survival from brain metastases were: Karnofsky performance status (KPS), the status of extracranial disease and age. Biological markers differentiating triple-negative group into basal-like and non-basal-like subtype (CK 5/6, HER1, c-KIT) had no influence on survival. In patients with triple-negative breast cancer and brain metastases, well-known clinical, but not molecular, features correlated with survival.
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| doi.org/10.1007/s11060-011-0616-3, hdl.handle.net/1765/26106 | |
| Journal of Neuro-Oncology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Niwińska, A., Olszewski, W., Murawska, M., & Pogoda, K. (2011). Triple-negative breast cancer with brain metastases: a comparison between basal-like and non-basal-like biological subtypes. Journal of Neuro-Oncology, 105(3), 547–553. doi:10.1007/s11060-011-0616-3 |
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