Immunoglobulin gene sequence analysis is widely utilized for prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called problematic sequences that do not fit the classic interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication.

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Erasmus MC: University Medical Center Rotterdam

Langerak, A.W, Davies, F, Ghia, P, Hadzidimitriou, A, Murray, F, Potter, K.N, … Belessi, C. (2011). Immunoglobulin sequence analysis and prognostication in CLL: Guidelines from the ERIC review board for reliable interpretation of problematic cases. Leukemia, 25(6), 979–984. doi:10.1038/leu.2011.49