2011-06-01
Educational paper: Primary antibody deficiencies
Publication
Publication
European Journal of Pediatrics , Volume 170 - Issue 6 p. 693- 702
Primary antibody deficiencies (PADs) are the most common primary immunodeficiencies and are characterized by a defect in the production of normal amounts of antigen-specific antibodies. PADs represent a heterogeneous spectrum of conditions, ranging from often asymptomatic selective IgA and IgG subclass deficiencies to the severe congenital agammaglobulinemias, in which the antibody production of all immunoglobulin isotypes is severely decreased. Apart from recurrent respiratory tract infections, PADs are associated with a wide range of other clinical complications. This review will describe the pathophysiology, diagnosis, and treatment of the different PADs.
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doi.org/10.1007/s00431-011-1474-x, hdl.handle.net/1765/26582 | |
European Journal of Pediatrics | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Driessen, G., & van der Burg, M. (2011). Educational paper: Primary antibody deficiencies. European Journal of Pediatrics (Vol. 170, pp. 693–702). doi:10.1007/s00431-011-1474-x |