Gastric cancer mortality has been fallen throughout Europe during the past decades in terms of both incidence and mortality rates. It is mainly as a result of remarkable improvement of life conditions in European societies. Efforts to reduce global cancer disparities begin with an understanding of geographic patterns of cancer incidence, mortality and prevalence rates, by studies such as GLOBOCAN, EUROCARE, and Five Continents databases. Survival increased and mortality decreased through the combination of earlier detection, better access to care and improved treatment. There has also been a concomitant change in lifestyle and environmental exposures over successive generations, including changes in exposures to risk factors in early decades of life.