Based on previous epidemiologic studies it is estimated that in the Netherlands the referral based prevalence of moderate to severe von Willebrand disease (VWD) is approximately 1 in 10,000 (1650 patients). This does not include patients with mild type 1 disease (VWF levels 30-50 U/dL), or individuals with borderline VWF levels with a mild bleeding phenotype, of which the prevalence is higher and may even reach 1:100 individuals. Despite the frequency of the disease only a limited number of studies have been performed on clinical presentation, determinants of bleeding phenotype and Quality of Life (QoL). Therefore we have initiated a nationwide study on moderate and severe VWD in the Netherlands, the Willebrand in the Netherlands study, the WiN study.

Netherlands, Willebrand disease, bleeding disorder, haemophilia
F.W.G. Leebeek (Frank)
Erasmus University Rotterdam
CSL Behring, Stichting Haemophilia
Erasmus MC: University Medical Center Rotterdam

de Wee, E.M. (2011, October 26). Von Willebrand Disease in the Netherlands. Erasmus University Rotterdam. Retrieved from