Worldwide esophageal cancer is a signifi cant and an increasing health problem. In 2005, there were 497,700 new cases, and the prevalence is expected to increase by approximately 140% by 2025. Esophageal squamous cell carcinoma (ESCC) accounts for most of the cases of esophageal cancer worldwide (2); however, in a number of Western countries, including the Netherlands, there has been a modest decline in the incidence of ESCC and a steep rise in the frequency of esophageal adenocarcinoma (EAC).

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The studies performed in this thesis were fi nancially supported by: The SK foundation, Stichting Erasmus Heelkundig Kankeronderzoek (SEHK) Revolving fund FC0991 Erasmus MC Rotterdam Financial support for the printing of this thesis was kindly provided by: Erasmus Universiteit Rotterdam Erasmus MC afdeling Heelkunde De Nederlandse Vereniging voor Gastroenterologie J. E. Jurriaanse Stichting
H.W. Tilanus (Hugo) , J.W. Oosterhuis (Wolter)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Boonstra, J. (2011, November 2). Translational Research on Esophageal Cancer: From Cell Line to Clinic. Retrieved from